AM-2201

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 AM-2201

 AM-2201  (also known as CBL-2201) is an indole-based synthetic cannabinoid that presumably  similar properties to the closely related 5F-PB-22 and NNE1, which are both full agonists and unselectively bind to CB1 and CB2 receptors with low nanomolar affinity

Full Chemical Name: AM-2201

Systematic IUPAC Name 1-[(5-fluoropentyl)-1H- indol-3-yl]-(naphthalen-1-yl) methanone
CAS Number 335161-24-5
ChemSpider Number 24751884
Molecular Formula C44H22FNO
Molecular Mass 359.435 g/mol

What is  AM-2201 ?

AM-2201 is a research chemical of the Cannabinoid family. At the Cannabinoid receptor, AM-2201 is a non selective full agonist. Discovered by Alexandros Makriyannis, AM-2201 is part of the AM Series of cannabinoid receptor ligand. AM-2201 is active at extremely low quantities, as low as 0.02g.

What is  AM-2201  used for?

Buy AM-2201 online can be used to further research the in vitro (outside living organism) efficacy it has upon the cannabinoid receptors. Due to its non-selectivity, AM-2201 is useful for broad ligand binding assays into the affinity (potency) and duration of action upon receptors. Affinities are: Ki of 1.0nM at CB1 and 2.6nM at CB2. AM-2201 can be combusted using heat to produce a vapour. This vapour is useful as it contains AM-2201 with a high surface area, enabling efficient contact when applied to a membrane containing cannabinoid receptors CB1 and CB2.

AM-2201may be used by chemical catalogue companies to analyse it using NMR, GC/MS,FTIR or HPLC. This analysis can be used by toxicology and forensic scientists as a reference for comparison. Chemists may also use AM-2201 as primary reagent for their specific studies

Hazards

Convulsions have been reported including at doses as low as 10 mg.

Recreational use of AM-2201 in the United States has led to it being specifically listed in a proposed 2011 amendment to the Controlled Substances Act, aiming to add a number of synthetic drugs into Schedule I.

Pharmacology

AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2. The 4-methyl functional analog MAM-2201 probably has similar affinities.[original research? AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors. AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity.

AM-2201

25g, 50g, 100g, 250, 500g, 1kg

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